Tlhokahalo ea litlhare
COVID-19 e bakoa ke ts'oaetso ea pathogen e ncha ea SARS-CoV-2, e kenang le ho kena liseleng tse amohelang batho ka protheine ea eona ea spike.Hajoale, ho na le linyeoe tse fetang limilione tse 138.3 lefatšeng ka bophara, 'me lenane la ba shoang le haufi le limilione tse tharo.
Leha liente li amohetsoe bakeng sa ts'ebeliso ea ts'ohanyetso, ho sebetsa ha tsona khahlano le mefuta e meng e mecha ho 'nile ha belaelloa.Ho feta moo, ts'ebetso ea ente ea bonyane 70% ea baahi linaheng tsohle tsa lefats'e e kanna ea nka nako e telele, ho nahanoa ka lebelo la ha joale la ente, khaello ea tlhahiso ea ente, le mathata a tsamaiso.
Lefatše le ntse le tla hloka lithethefatsi tse sebetsang hantle le tse sireletsehileng, ka hona, ho kenella bokuli bo tebileng bo bakoang ke vaerase ena.Tlhahlobo ea morao-rao e shebane le mosebetsi oa motho ka mong le oa synergistic oa curcumin le nanostructures khahlanong le kokoana-hloko.

Tlhokahalo ea litlhare
COVID-19 e bakoa ke ts'oaetso ea pathogen e ncha ea SARS-CoV-2, e kenang le ho kena liseleng tse amohelang batho ka protheine ea eona ea spike.Hajoale, ho na le linyeoe tse fetang limilione tse 138.3 lefatšeng ka bophara, 'me lenane la ba shoang le haufi le limilione tse tharo.
Leha liente li amohetsoe bakeng sa ts'ebeliso ea ts'ohanyetso, ho sebetsa ha tsona khahlano le mefuta e meng e mecha ho 'nile ha belaelloa.Ho feta moo, ts'ebetso ea ente ea bonyane 70% ea baahi linaheng tsohle tsa lefats'e e kanna ea nka nako e telele, ho nahanoa ka lebelo la ha joale la ente, khaello ea tlhahiso ea ente, le mathata a tsamaiso.
Lefatše le ntse le tla hloka lithethefatsi tse sebetsang hantle le tse sireletsehileng, ka hona, ho kenella bokuli bo tebileng bo bakoang ke vaerase ena.Tlhahlobo ea morao-rao e shebane le mosebetsi oa motho ka mong le oa synergistic oa curcumin le nanostructures khahlanong le kokoana-hloko.

Curcumin
Curcumin ke motsoako oa polyphenolic o arohaneng le rhizome ea semela sa turmeric, Curcuma longa.E etsa curcuminoid e kholo semeleng sena, ho 77% ea kakaretso, ha motsoako o monyenyane oa curcumin II o etsa 17%, 'me curcumin III e na le 3%.
Curcumin e 'nile ea khetholloa' me ea ithutoa ka botlalo, e le molek'hule ea tlhaho e nang le meriana.Ho mamella le polokeho ea eona ho tlalehiloe hantle, ka tekanyo e phahameng ea 12 g / letsatsi.
Tšebeliso ea eona e hlalositsoe e le anti-inflammatory, anticancer, antioxidant, hammoho le antiviral.Curcumin e khothalelitsoe e le molek'hule e nang le monyetla oa ho folisa pulmonary edema le lits'ebetso tse ling tse kotsi tse lebisang ho lung fibrosis kamora COVID-19.

Curcumin e thibela li-enzyme tsa kokoana-hloko
Ho nahanoa hore sena se bakoa ke bokhoni ba eona ba ho thibela kokoana-hloko ka boeona, hammoho le ho fetola litsela tsa ho ruruha.E laola ho ngolisoa ha kokoana-hloko le taolo, e tlama ka matla a phahameng ho enzyme ea viral main protease (Mpro) eo e leng senotlolo sa ho ikatisa le ho thibela kokoana-hloko le ho kena ka seleng e amohelang.E ka boela ea senya likarolo tsa kokoana-hloko.
Lipheo tsa eona tse fapaneng tsa antiviral li kenyelletsa kokoana-hloko ea hepatitis C, kokoana-hloko ea ho itšireletsa mafung (HIV), kokoana-hloko ea Epstein-Barr le kokoana-hloko ea ntaramane A.Ho tlalehiloe hore e thibela 3C-like protease (3CLpro) ka katleho ho feta lihlahisoa tse ling tsa tlhaho, ho kenyeletsoa quercetin, kapa lithethefatsi tse kang chloroquine le hydroxychloroquine.
Sena se ka lumella phokotso ea bongata ba kokoana-hloko ka har'a sele ea motho ka potlako haholo ho feta lithethefatsi tse ling tse fokolang, 'me kahoo ho thibela tsoelo-pele ea mafu ho lefu la acute breathing distress syndrome (ARDS).
E boetse e thibela papain-like protease (PLpro) e nang le 50% inhibitory concentration (IC50) ea 5.7 µM e fetang quercetin le lihlahisoa tse ling tsa tlhaho.

Curcumin e thibela ho amohela li-cell cell
Kokoana-hloko e hokahana le receptor ea sele e lebeletsoeng ke batho, e leng enzyme 2 e fetolang angiotensin (ACE2).Boithuto ba mohlala bo bonts'itse hore curcumin e thibela tšebelisano ena ea vaerase-receptor ka mekhoa e 'meli, ka ho thibela protheine ea spike le receptor ea ACE2.
Leha ho le joalo, curcumin e na le bioavailability e tlaase, hobane ha e qhibilihe hantle metsing 'me e tsitsitse mecheng ea metsi, haholo-holo pH e phahameng.Ha e fanoa ka molomo, e kena ka potlako metabolism ka mala le sebete.Tšitiso ena e ka hlōloa ka ho sebelisa nanosystems.
Mefuta e mengata e fapaneng ea li-nanostructured carriers e ka sebelisoa bakeng sa morero ona, joalo ka nanoemulsions, microemulsions, nanogels, micelles, nanoparticles le liposomes.Lijari tse joalo li thibela ho senyeha ha metabolism ea curcumin, li eketsa ho qhibiliha ha eona le ho li thusa ho tsamaea ka har'a li-membrane tsa likokoana-hloko.
Lihlahisoa tse tharo kapa ho feta tsa curcumin tse thehiloeng ho nanostructure li se li ntse li fumaneha khoebong, empa lithuto tse fokolang li hlahlobile katleho ea tsona khahlanong le COVID-19 in vivo.Tsena li bontšitse bokhoni ba metsoako ea ho fetola likarabo tsa 'mele oa ho itšireletsa mafung le ho fokotsa matšoao a lefu lena, mohlomong le ho potlakisa ho hlaphoheloa.